Former Vice President Mike Pence filed paperwork on Monday declaring his campaign for president in 2024.
Mr Pence, 63, is set to formally launch his campaign with a video, speech and townhall event in the early voting state of Iowa on Wednesday.
The move pits him against Donald Trump, the man he served in the White House for four years from 2017-21.
The former president is currently polling well ahead in the race.
Most opinion polls show Mr Pence in a distant third place, with support in the low single digits.
The former Indiana governor and congressman is expected to position himself as a continuation of the Trump administration's conservative agenda, without the baggage.
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